| Identification | Back Directory | [Name]
BRUSATOL | [CAS]
114420-67-6 | [Synonyms]
BRUSATOL
Regaloside B
β-D-Glucopyranoside, (1S)-2-(acetyloxy)-1-[[[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]methyl]ethyl | [Molecular Formula]
C26H32O11 | [MDL Number]
MFCD01746220 | [MOL File]
114420-67-6.mol | [Molecular Weight]
442.41 |
| Questions And Answer | Back Directory | [Description]
Brusatol is a natural quassinoid that shows a potential therapeutic use in cancer models by the inhibition of Nuclear factor erythroid 2-related factor 2 (Nrf2) and is capable of inducing a variety of biological effects. The effects of Brusatol on oocyte meiosis has not been addressed. |
| Hazard Information | Back Directory | [Uses]
Clinically, the research shows brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism, and it provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity. Brusatol overcomes chemoresistance through inhibition of protein translation. | [storage]
Store at -20°C |
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