ChemicalBook--->CAS DataBase List--->1228763-95-8

1228763-95-8

1228763-95-8 Structure

1228763-95-8 Structure
IdentificationBack Directory
[Name]

Monalizumab
[CAS]

1228763-95-8
[Synonyms]

Monalizumab
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[Water Solubility ]

Soluble in water
Hazard InformationBack Directory
[Uses]

Monalizumab (IPH2201) is a potentially first-in-class immune checkpoint inhibitor targeting NKG2A receptors expressed on tumor infiltrating cytotoxic CD8+ T cells and NK cells.
[Mechanism of action]

Monalizumab is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. By acting simultaneously on innate and adaptive immunity, monalizumab may re-establish a broad anti-tumor response.
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