| Identification | Back Directory | [Name]
4-AMINOPHENYLARSONIC ACID SODIUM SALT | [CAS]
127-85-5 | [Synonyms]
soamin
sonate
ATOXYL
arsamin
nuarsol
trypoxyl
protoxyl
nci-c61176
Chebi:36049
arsinosolvin
nci-61176[qr]
pro-gensodium
pigletpro-genv
ai3-29289-x[qr]
sodiumarsonilate
SODIUM ARSANILATE
pigletpro-genv[qr]
sodiump-arsanilate
sodiumanilarsonate
sodiumaminarsonate
sodiumanilarsonate[qr]
sodium-analinearsonate
arsanilicacidsodiumsalt
4-Arsanilic Acid Sodium
anhydroussodiumarsanilate
sodiumaminophenolarsonate
sodiumaniline-arsonate[qr]
sodiump-aminophenylarsonate
sodiump-aminobenzenearsonate
arsanilicacid,sodiumsalt[qr]
P-ARSANILIC ACID SODIUM SALT
SODIUM 4-AMINOPHENYLARSONATE
anhydroussodiumarsanilate[qr]
sodiumaminophenolarsonate[qr]
sodiumaminophenylarsonate[qr]
Arsanilic acid，monosodium salt
monosodium(4-aminophenyl)arsonate
sodium hydrogen 4-aminophenylarsonate
4-AMINOPHENYLARSONIC ACID SODIUM SALT
sodium:(4-aminophenyl)-hydroxyarsinate
Sodium 4-Aminophenylarsonate USP/EP/BP
4-AMINOBENZENEARSONIC ACID SODIUM SALT
(4-aminophenyl)-arsonicacimonosodiumsalt
(4-aminophenyl)arsonicacid,sodiumsalt[qr]
4-AMINOPHENYLARSONIC ACID SODIUM SALT HYDRATE
Arsonic acid, (4-aminophenyl)-, monosodium salt
4-Aminobenzenearsonic Acid Sodium Salt
p-Arsanilic Acid Sodium Salt
Atoxyl
4-Aminophenylarsonic Acid Sodium Salt
Sodium Arsanilate
Sodium Hydrogen 4-Aminophenylarsonate | [EINECS(EC#)]
204-869-9 | [Molecular Formula]
C6H6AsNNa2O3 | [MDL Number]
MFCD00067431 | [MOL File]
127-85-5.mol | [Molecular Weight]
261.02 |
| Safety Data | Back Directory | [Risk Statements ]
26/27/28 | [Safety Statements ]
26-36/37/39 | [RIDADR ]
2473 | [RTECS ]
CF9625000 | [HS Code ]
2920.90.2000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Safety Profile]
Poison by
subcutaneous route. Can cause blindness.
When heated to decomposition it emits very
toxic fumes of As and NOx. | [Hazardous Substances Data]
127-85-5(Hazardous Substances Data) | [Toxicity]
LD50 scu-rat: 75 mg/kg BIZEA2 184,360,27 |
| Hazard Information | Back Directory | [General Description]
A white crystalline, odorless powder. Slightly denser than water. Contact may irritate skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals. | [Air & Water Reactions]
Soluble in water. | [Health Hazard]
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Fire Hazard]
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. | [Definition]
ChEBI: Sodium arsanilate is an organoarsonic acid salt and an organic sodium salt. It has a role as an antisyphilitic drug. It contains an arsanilate(1-). | [Pharmaceutical Applications]
Bechamp,teaching medicinal chemistry at the University of Montpellier, synthesised in 1863 a compound from aniline and arsenic acid, which became known later as Atoxyl. The name Atoxyl stems from its decreased toxicity. Bechamp characterised his compound as an anilide.
In 1905, Thomas and Breinl showed that Atoxyl was effective in the treatment of trypanosomas, mainly Trypanosoma brucei gambiense-the cause of the African sleeping sickness, which was the main health problem around that time in Africa. Nevertheless, very high doses were required to show any pronounced effect, and as a result severe side effects such as blindness and damage to the optical nerve were common issues.
Inspired by this research, Ehrlich hired the chemist Bertheim in 1905. Bertheim revised the structure of Atoxyl and the correct chemical formula was assigned. Atoxyl was identified as an p-anilinyl arsenic acid derivative on the basis of its properties to reduce Tollen’s reagent [Ag(NH3)2]+ to metallic silver and its potential use to synthesise the corresponding diazo dye. |
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