| Identification | Back Directory | [Name]
2-IMINOBIOTIN HYDROBROMIDE | [CAS]
13395-35-2 | [Synonyms]
Iminobiotin
2-IMINOBIOTIN
2-Iminobiotine
GUANIDINOBIOTIN
2-IMINOBIOTIN 98+%
2- Iminobiotin 13395-35-2
2-Iminobiotin >=98% (TLC)
2-IMINOBIOTIN HYDROBROMIDE
Tetrahydro-2-iminothieno[3,4-d]imidazoline-4-valeric acid
HEXAHYDRO-2-IMINO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID
Guanidinobiotin, Hexahydro-2-imino-1H-thieno[3,4-d]imidazole-4-pentanoic acid
5-[(3aS,4S,6aR)-2-imino-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanoic acid
(3aR,6S,6aS)-2-Amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-6-pentanoic acid
1H-Thieno[3,4-d]iMidazole-6-pentanoicacid, 2-aMino-3a,4,6,6a-tetrahydro-, (3aR,6S,6aS)-
5-((3aR,6S,6aS)-2-Amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl)pentanoic acid
5-[(3aS,4S,6aR)-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid
Iminobiotin
(3aR,6S,6aS)-2-Amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-6-pentanoic acid
5-((2S,3S,4R)-3,4-diaminotetrahydrothiophen-2-yl)pentanoic acid compound with sulfuric acid (1:1) | [Molecular Formula]
C10H17N3O2S | [MDL Number]
MFCD07391178 | [MOL File]
13395-35-2.mol | [Molecular Weight]
243.33 |
| Chemical Properties | Back Directory | [Boiling point ]
477.3±55.0 °C(Predicted) | [density ]
1.60 | [storage temp. ]
2-8°C | [solubility ]
1 M HCl: 50 mg/mL, clear, colorless
| [form ]
White to off-white powder. | [pka]
4.73±0.10(Predicted) | [BRN ]
18952 |
| Hazard Information | Back Directory | [Uses]
2-Iminobiotin has been used as a competitive inhibitor to bind to biotic binding sites on streptavidin in order to restore fluorescence signal. | [General Description]
2-Iminobiotin is a cyclic guanidino analog of biotin that has high affinity for avidin at high pH (>9) and low affinity at low pH (<6). The proteins that are iminobiotinylated are selectively contained within the avidin column at pH 9 to 11 and may be eluted at pH 4 or by the addition of biotin. This technique may be very useful in the study of cell surface proteins by labeling and selectively recovering the components that are periodate-sensitive from intact human erythrocyte surface. 2-Iminobiotin reversibly inhibits NOS (nitric oxide synthases) via its guanidino group. It inhibits NO biosynthesis and may be important to understand the binding-site interactions for this important class of enzymes. NOS oxidizes the guanidino-nitrogen of L-arginine to produce nitric oxide and L-citrulline. |
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