| Identification | Back Directory | [Name]
Cilofexor | [CAS]
1418274-28-8 | [Synonyms]
CS-2761
Cilofexor
Cilofexor （GS-9674)
GS-9674;GS9674;CILOFEXOR
2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic acid
4-Pyridinecarboxylic acid, 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]-
2-[3-(2-chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid | [Molecular Formula]
C28H22Cl3N3O5 | [MDL Number]
MFCD31731099 | [MOL File]
1418274-28-8.mol | [Molecular Weight]
586.85 |
| Chemical Properties | Back Directory | [Boiling point ]
855.5±65.0 °C(Predicted) | [density ]
1.538±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:32.5(Max Conc. mg/mL);55.38(Max Conc. mM) | [form ]
A crystalline solid | [pka]
2.10±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay).1 It has FXR agonist activity in a mammalian one hybrid (M1H) assay (EC50 = ≥100 nM). | [storage]
Store at -20°C |
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