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1426916-02-0

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1426916-02-0 Structure

1426916-02-0 Structure
IdentificationBack Directory
[Name]

ML298
[CAS]

1426916-02-0
[Synonyms]

ML298
ML298 >=98% (HPLC)
Benzamide, 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-
[Molecular Formula]

C22H23F3N4O2
[MOL File]

1426916-02-0.mol
[Molecular Weight]

432.44
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

ML-298 is an inhibitor of phospholipase D2 (PLD2; IC50 = 355 nM). It is selective for PLD2 over PLD1 (IC50 = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 μM without inducing cytotoxicity.
[Uses]

ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2).
[Biochem/physiol Actions]

ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2; IC50 = 355 nM). ML298 does not affect PLD1 activity at concentrations up to 20 μM.
[storage]

Store at -20°C
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