| Identification | Back Directory | [Name]
N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE | [CAS]
149649-22-9 | [Synonyms]
NAFADOTRIDE
N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
2-Naphthalenecarboxamide, N-[(1-butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy- | [Molecular Formula]
C22H27N3O2 | [MDL Number]
MFCD00920172 | [MOL File]
149649-22-9.mol | [Molecular Weight]
365.47 |
| Chemical Properties | Back Directory | [Boiling point ]
556.6±40.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [pka]
12.84±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
Nafadotride is a highly potent and competitive dopamine D3 receptor (D3R) antagonist. | [Definition]
ChEBI: A naphthalenecarboxamide resulting from the formal condensation of the carboxylic acid group of 4-cyano-1-methoxynaphthalene-2-carboxylic acid with the primary amino group of 1-(1-butylpyrrolidin-2-yl]methanamine. It is a highly potent, competitive, prefer
ntial dopamine D3 receptor antagonist, centrally active upon systemic administration. | [Biological Activity]
Highly potent, competitive, preferential dopamine D 3 receptor antagonist. K i values are 0.52, 5, and 269 nM for human cloned D 3 , D 2 and D 4 receptors respectively. Centrally active upon systemic administration. |
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