| Identification | Back Directory | [Name]
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide | [CAS]
168835-82-3 | [Synonyms]
CS-1481
CHEMBL261508
SU1498, >98%
Tyrphostin SU 1498, >98%
(E)-2-CYANO-3-(4-HYDROXY-3
AG-1498;TYRPHOSTIN SU 1498
5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
2-Propenamide, 2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-, (2E)-
SU1498; TYRPHOSTIN SU 1498; CHEMBL261508; (E)-2-CYANO-3-(4-HYDROXY-3;5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE
Vascular endothelial growth factor receptor,Inhibitor,Su-1498,AG1498,AG-1498,Su1498,Tyrphostin SU1498,inhibit,Tyrphostin SU-1498,VEGFR,SU 1498 | [Molecular Formula]
C25H30N2O2 | [MDL Number]
MFCD03453026 | [MOL File]
168835-82-3.mol | [Molecular Weight]
390.518 |
| Chemical Properties | Back Directory | [Melting point ]
126 °C | [Boiling point ]
590.6±50.0 °C(Predicted) | [density ]
1.100±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO. | [form ]
powder | [pka]
10.30±0.36(Predicted) | [color ]
white to beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | [CAS DataBase Reference]
168835-82-3 |
| Hazard Information | Back Directory | [Description]
SU-1498 (168835-82-3) is a potent, reversible, selective inhibitor of VEGFR-2, also known as Flk-1 (IC50 = 700 nM). Inhibition of VEGFR-2 blocks angiogenesis in both in vitro and in vivo models. Cell permeable. | [Uses]
SU 1498 is an inhibitor of VEGF receptor kinase. | [Definition]
ChEBI: SU1498 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enoic acid with the amino group of 3-phenylpropylamine. It has a role as a vascular endothelial growth factor receptor antagonist. It is an enamide, a member of phenols, a nitrile, a monocarboxylic acid amide and a secondary carboxamide. | [Biochem/physiol Actions]
SU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1 with an IC50 value of 700 nM. SU1498 is a very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase with IC50 values > 50 μM. SU1498 has been used to study the role of VEGFR2 (Flk-1) in a variety of biological activities including angiogenesis, tumor growth inhibition, and stem cell proliferation. | [storage]
Store at -20°C | [References]
1) Cho et al. (2005), Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor; Am. J. Respir. Cell Mol. Biol., 33 622
2) Wang et al. (2002), Interplay between integrins and FLK-1 in shear stress-induced signaling; Am. J. Physiol. Cell Physiol., 283 C1540
3) Strawn et al. (1996), FLK-1 as a target for tumor growth inhibition; Cancer Res., 56 3540 |
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