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168835-90-3

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168835-90-3 Structure

168835-90-3 Structure
IdentificationBack Directory
[Name]

Tyrphostin AG1433
[CAS]

168835-90-3
[Synonyms]

1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)-
[Molecular Formula]

C16H14N2O2
[MOL File]

168835-90-3.mol
[Molecular Weight]

266.29
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 62.5 mg/mL (234.71 mM)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H312-H332
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501
Spectrum DetailBack Directory
[Spectrum Detail]

Tyrphostin AG1433(168835-90-3)1HNMR
Hazard InformationBack Directory
[Biological Activity]

Tyrphostin AG1433 (SU1433) is a tyrosine kinase inhibitor. It is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50 of 5.0 μM and 9.3 μM, respectively. It prevents blood vessel formation.
[in vivo]

Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day- old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets.

[target]

Flk-1

< span> 9.3 μM (IC 50 )

PDGFRβ

5 μM (IC 50 )

[storage]

Store at -20°C
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