| Identification | Back Directory | [Name]
Exatecan mesilate | [CAS]
169869-90-3 | [Synonyms]
DX 8951f
Exatecan Meslate
Exatecan mesilate
169869-90-3 （free base）
DX8951F;DX 8951F;DX-8951F
Exatecan?Mesylate top3
Exatecan Mesylate (DX8951f)
Exatecan (DX-8951) mesylate
DX 8951; DX 8951;169869-90-3 (FREE BASE)
(1S,9S)-1-AMINO-9-ETHYL-5-FLUORO-9-HYDROXY-4-METHYL-2,3,9,10,13,15-HEXAHYDRO-1H,12H-BENZO[DE]PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-10,13-DIONE MESYLATE | [Molecular Formula]
C24H22FN3O4.CH4O3S | [MOL File]
169869-90-3.mol | [Molecular Weight]
531.56 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, protect from light, stored under nitrogen | [solubility ]
DMSO:7.41(Max Conc. mg/mL);13.94(Max Conc. mM)
Water:0.0(Max Conc. mg/mL);0.19(Max Conc. mM) | [form ]
A solid | [Stability:]
Hygroscopic | [InChIKey]
BICYDYDJHSBMFS-OVCYJQQENA-N | [SMILES]
S(O)(=O)(=O)C.N[C@H]1CCC2C(C)=C(F)C=C3N=C4C5=CC6[C@@](C(=O)OCC=6C(=O)N5CC4=C1C3=2)(O)CC |&1:6,21,r| |
| Hazard Information | Back Directory | [Description]
Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogs. | [Uses]
Exatecan Mesylate (DX8951f) is a topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) for cancer research. | [Synthesis]
The synthesis of Exatecan mesilate is as follows:
500mL reaction flask,To a suspension of compound II (15 g, 1.0 eq) in ethylene glycol monomethyl ether (150 mL),After adding methanesulfonic acid (75 mL) and water (75 mL) under cooling,The solution was heated under reflux for 24 hours,The reaction was complete as detected by LCMS and cooled to 25°C.Remove the solvent under reduced pressure, add 2L methanol, stir for 2 hours and filter,The filter cake was washed with 200 mL methanol,Dry to obtain 9g of yellow ixitecan mesylate crude product,Yield 53.9%, HPLC purity: 96%.
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