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177583-70-9

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177583-70-9 Structure

177583-70-9 Structure
IdentificationBack Directory
[Name]

ZK164015
[CAS]

177583-70-9
[Synonyms]

ZK 164015
2-(4-HYDROXYPHENYL)-3-METHYL-1-[10-(PENTYLSULFONYL)DECYL]-1H-INDOL-5-OL
[Molecular Formula]

C30H43NO4S
[MDL Number]

MFCD06798325
[MOL File]

177583-70-9.mol
[Molecular Weight]

513.73
Chemical PropertiesBack Directory
[storage temp. ]

Store at RT
[solubility ]

Soluble to 25 mM in ethanol and to 100 mM in DMSO
[form ]

Powder
Hazard InformationBack Directory
[Uses]

ZK 164015 is a potent ER silent antagonist.
[Definition]

ChEBI: 2-(4-hydroxyphenyl)-3-methyl-1-(10-pentylsulfonyldecyl)-5-indolol is a phenylindole.
[Biological Activity]

Potent  estrogen  receptor  silent  antagonist.  Inhibits  17b-estradiol  stimulation  of  luciferase  activity  (IC  50 =  0.025  mM)  and  potently  inhibits  the  growth  of  estrogen-sensitive  human  MCF-7  breast  cancer  cells in  vitro (IC  50 ~  1  nM).
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