| Identification | Back Directory | [Name]
Propargyl-PEG2-acid | [CAS]
1859379-85-3 | [Synonyms]
CAS_1859379-85-3
Propargyl-PEG2-acid
Propargyl-PEG1-COOH
Propyne-PEG1-CH2CH2COOH
3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid
3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid
Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]- | [Molecular Formula]
C8H12O4 | [MDL Number]
MFCD29764323 | [MOL File]
1859379-85-3.mol | [Molecular Weight]
172.18 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG2-acid is a linker consisting of propargyl and carboxylic acid functional groups. In the presence of activators (e.g. EDC, or HATU), the carboxylic acid reacts with primary amine to form a stable amide bond. The propargyl group reacts with azide group in biomolecules to yield a stable triazole linkage. | [Uses]
Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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