| Identification | Back Directory | [Name]
Vitamin K2(35) | [CAS]
2124-57-4 | [Synonyms]
MK-7
Vitamin MK 7
MENAQUINONE-7
Menaquinone K7
Vitamin K2(35)
Menlaquinone 7
Menaquinone-7 Standard
Menaquinone 7, Synthetic
Menaquinone 7, Synthetic (90%)
(all-E)-2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione
2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptenyl]-3-methyl-1,4-naphthalenedione | [Molecular Formula]
C46H64O2 | [MDL Number]
MFCD06200757 | [MOL File]
2124-57-4.mol | [Molecular Weight]
649 |
| Chemical Properties | Back Directory | [Appearance]
Light Yellow Crystalline Solid | [Melting point ]
54 °C | [Boiling point ]
bp0.0002 200° (some dec) | [density ]
0.961 | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow to Yellow Gel to | [Stability:]
Light and Temperature Sensitive | [InChIKey]
RAKQPZMEYJZGPI-LJWNYQGCSA-N | [SMILES]
C1(=O)C2=C(C=CC=C2)C(=O)C(C)=C1C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C)\C | [LogP]
14.451 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Crystalline Solid | [Uses]
Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari
ety of physiological processes. Menaquinone 7 belongs to the class of K2-Vitamins homologs. Menaquinone 7 has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-prote
ins such as osteocalcin and matrix-Gla protein, which plays a crucial role in building and maintaining overall bone health. | [Uses]
Vitamin (prothrombogenic) | [Definition]
ChEBI: A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation. | [Description]
Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods.1 It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 μM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats.2 In vivo, MK-7 (100 μg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification.3 It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.4 | [General Description]
Vitamin K2, also known as menaquinone, is a polyisoprenoid-substituted?napthoquinone. Menaquinone-7 (MK-7) is a subtype of vitamin K2. It is found in animals, soy protein, fermented products and is primarily produced by bacteria.
Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) is a deuterated vitamin K2 wherein C-5, C-6, C-7, C-8, and 2-methyl protons are replaced by deuterium. |
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