| Identification | Back Directory | [Name]
MPEG16-Propyne | [CAS]
2169967-47-7 | [Synonyms]
MPEG16-Propyne
2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxatripentacont-52-yne | [Molecular Formula]
C36H70O17 | [MDL Number]
MFCD27977517 | [MOL File]
2169967-47-7.mol | [Molecular Weight]
774.93 |
| Hazard Information | Back Directory | [Biological Activity]
Propargyl-PEG17-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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