| Identification | Back Directory | [Name]
m-PEG8-ethoxycarbonyl-propanoic acid | [CAS]
2353409-75-1 | [Synonyms]
m-PEG8-ethoxycarbonyl-propanoic acid
3-(m-PEG8-ethoxycarbonyl)propanoic acid | [Molecular Formula]
C21H40O12 | [MDL Number]
MFCD31811487 | [MOL File]
2353409-75-1.mol | [Molecular Weight]
484.54 |
| Hazard Information | Back Directory | [Biological Activity]
m-PEG8-ethoxycarbonyl-propanoic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
|
|