| Identification | Back Directory | [Name]
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 | [CAS]
352017-71-1 | [Synonyms]
AY-NH
AY-NH2
PAR4-AP
AYPGKF-NH2
AYPGKFAMIDE
PAR-4 aMide, Mouse
PAR-4 AGONIST AMIDE
ALA-TYR-PRO-GLY-LYS-PHE-NH2
PAR-4 Agonist Peptide, amide
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
(ALA1)-PAR-4 (1-6) AMIDE (MOUSE)
PAR-4 Agonist Peptide, amide(2TFA)
PAR-4 Agonist Peptide, amide (PAR-4-AP
PROTEASE-ACTIVATED RECEPTOR-4 AGONIST AMIDE
Proteinase activated receptor 4 amide, mouse
Proteinase-Activated Receptor 4 Activating Peptide
(ALA1)-THROMBIN RECEPTOR-LIKE 3 (1-6) AMIDE (MOUSE)
Protease-Activated Receptor-4, PAR-4 Agonist, amide
(ALA1)-PROTEINASE ACTIVATED RECEPTOR 4 (1-6) AMIDE (MOUSE)
L-Phenylalaninamide, L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-
(ALA1)-COAGULATION FACTOR II RECEPTOR-LIKE 3 (1-6) AMIDE (MOUSE)
AY-NH2;PAR4-AP;PROTEINASE-ACTIVATED RECEPTOR 4 ACTIVATING PEPTIDE
AYPGKF-NH2 Selective Protease-Activated Receptor 4 (PAR4) Agonist
Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt >=98% (HPLC), solid
(Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt
AYPGKFaMide, (Ala1)-ThroMbin Receptor-Like 3 (1-6) aMide (Mouse), (Ala1)-Coagulation Factor II Receptor-Like 3 (1-6) aMide (Mouse), (Ala1)-Proteinase Activated Receptor 4 (1-6) aMide (Mouse)
(2S)-N-[2-[[(2S)-6-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide | [Molecular Formula]
C34H48N8O7 | [MDL Number]
MFCD06796234 | [MOL File]
352017-71-1.mol | [Molecular Weight]
680.79 |
| Chemical Properties | Back Directory | [Boiling point ]
1143.1±65.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
Soluble in H2O | [form ]
solid | [pka]
9.84±0.15(Predicted) | [Water Solubility ]
Soluble in water |
| Hazard Information | Back Directory | [Uses]
AY-NH2 is used in the synthetic preparation of PAR4 agonist peptides towards PAR4 receptor activation. | [Biological Activity]
ay-nh2 is a selective agonist of par4 with ec50 value of 11 μm [1].protease-activated receptor-4 (par4) is a member of pars and plays an important role in mediating cellular effects of thrombin through acting g-proteins i, 12/13 (rho and ras activation) and q (calcium signaling) [2].ay-nh2 is a potent par4 agonist and has a higher (~10 fold) activity than gypgkf-nh2. using rat platelet aggregation assay, it was shown that ay-nh2 had highly platelet aggregation ability than gy-nh2 and gf-nh2 [1]. when tested with platelet-rich plasma harvested from wild-type c57bl6 mice, ay-nh2 treatment exhibited highly agonist activity on par4 while had no effect on other pars [3].in male wistar rats model of paw oedema, i.pl. injection of ay-nh2 markedly reduced the nociceptive score in response to both noxious and non-noxious mechanical stimuli, thus inhibiting carrageenan-induced mechanical hyperalgesia and allodynia [4]. | [storage]
Store at -20°C | [References]
[1]. hollenberg, m.d., et al., proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. br j pharmacol, 2004. 143(4): p. 443-54.
[2]. yu, g., et al., increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. plos one, 2015. 10(4): p. e0122678.
[3]. faruqi, t.r., et al., structure-function analysis of protease-activated receptor 4 tethered ligand peptides. determinants of specificity and utility in assays of receptor function. j biol chem, 2000. 275(26): p. 19728-34.
[4]. asfaha, s., et al., protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. br j pharmacol, 2007. 150(2): p. 176-85. |
|
|