| Identification | Back Directory | [Name]
Colestipol hydrochloride | [CAS]
37296-80-3 | [Synonyms]
lestid
colestid
cholestabyl
COLESTIPOL HCL
COLESTIPOL HYDROCHLORIDE
Colestipol Hydrochloride (200 mg)
Colestipol Hydrochloride (1146505)
n'-(2-aminoethyl)-n-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine 2-(chloromethyl)oxirane hydrochloride
N-(2-AMINOETHYL)-N'-[2-[(2-AMINOETHYL)AMINO]ETHYL]-1,2-ETHANEDIAMINE POLYMER WITH (CHLOROMETHYL)OXIRANE HYDROCHLORIDE | [Molecular Formula]
C8H24ClN5 | [MDL Number]
MFCD01770708 | [MOL File]
37296-80-3.mol | [Molecular Weight]
225.763 |
| Safety Data | Back Directory | [WGK Germany ]
3 | [HS Code ]
3914006000 | [Toxicity]
LD50 in rats (mg/kg): >4000 i.p.; >1000 orally (Webster, Bollert) |
| Hazard Information | Back Directory | [Uses]
Antihyperlipidemic. | [Uses]
Colestipol Hydrochloride was useful for studying pharmacokinetics with Teriflunomide (A771726). | [Definition]
ChEBI: The hydrochloride of colestipol, a highly cross-linked, high molecular weight copolymer of diethylenetriamine and epichlorohydrin (hydrochloride), with approximately 1 out of 5 amine nitrogens protonated. It is used for binding bile acids in the intestine,
inhibiting their reabsorption. | [Brand name]
Colestid (Pharmacia & Upjohn). | [General Description]
Colestipol (Colestid) is ahigh–molecular-weight, insoluble, granular copolymer oftetraethylenepentamine and epichlorohydrin. It functions asan anion-exchange, resin-sequestering agent in a manner similarto that of cholestyramine resin. Colestipol hydrochloridereduces cholesterol levels without affecting triglycerides andseems to be especially effective in the treatment of type IIhyperlipoproteinemias. | [Drug interactions]
Potentially hazardous interactions with other drugs
Anticoagulants: may enhance or reduce effects of
coumarins and phenindione.
Ciclosporin: no reports of an interaction; however,
ciclosporin levels should be carefully monitored if
colestipol and ciclosporin are prescribed concurrently,
as colestipol may interfere with ciclosporin
absorption. | [Metabolism]
Not applicable as colestipol is not systemically absorbed. |
|
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LGM Pharma
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1-(800)-881-8210 |
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www.lgmpharma.com |
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DC Chemicals
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Pharma Affiliates
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https://www.chemicalbook.com/ShowSupplierProductsList694812/0.htm |
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