ChemicalBook--->CAS DataBase List--->4382-56-3

4382-56-3

4382-56-3 Structure

4382-56-3 Structure
IdentificationBack Directory
[Name]

PERAKINE
[CAS]

4382-56-3
[Synonyms]

PERAKINE
Aids003043
Aids-003043
Raucaffrine
Indole alkaloid
(17R,20α)-19-Oxo-1,2-didehydro-1-demethyl-21β-methyl-18-norajmalan-17-ol acetate
18-Norajmalan-19-al, 17-(acetyloxy)-1,2-didehydro-1-demethyl-21-methyl-, (17R,20A,21B)-
18-Norajmalan-19-al, 17-(acetyloxy)-1,2-didehydro-1-demethyl-21-methyl-, (17R,20α,21β)-
(13R)-13-Acetyloxy-7aα,2α,6α-ethan[1]yl[2]ylidene-1,2,3,4,6,7,7a,12bβ-octahydro-4α-methylindolo[2,3-a]quinolizine-3β-carbaldehyde
[Molecular Formula]

C21H22N2O3
[MOL File]

4382-56-3.mol
[Molecular Weight]

350.42
Chemical PropertiesBack Directory
[Melting point ]

186 °C
[Boiling point ]

492.8±45.0 °C(Predicted)
[density ]

1.59±0.1 g/cm3(Predicted)
[pka]

5.38±0.70(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

This alkaloid has been shown to be identical with Perakine (q.v.).
[Uses]

Perakine is an alkaloid extracted from family of Rauvolfia plants which acts as an inhibitor of aldose reductase, a potent drug target for diabetes.
[Definition]

ChEBI: An indole alkaloid having a ajmalan-type skeleton and characterised by a 17alpha-acetoxy group, a 21beta-methyl group, loss of the 1-methyl group with associated unsaturation at N(1)2C(2), and a 20alph -formyl group in place of the 20beta-ethyl side-chain.
[References]

Khan, Khan, Siddiqui., Pakistan 1. Sci. Ind. Res., 8, 23 (1965)
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