| Identification | Back Directory | [Name]
holomycin | [CAS]
488-04-0 | [Synonyms]
holomycin
N-Demethylthiolutin
N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)- | [Molecular Formula]
C7H6N2O2S2 | [MDL Number]
MFCD01670588 | [MOL File]
488-04-0.mol | [Molecular Weight]
214.26 |
| Hazard Information | Back Directory | [Definition]
ChEBI: Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as a chelator, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, an antibacterial agent, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 86, p. 5654, 1964 DOI: 10.1021/ja01078a049 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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