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518357-51-2

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518357-51-2 Structure

518357-51-2 Structure
IdentificationBack Directory
[Name]

3-MATIDA
[CAS]

518357-51-2
[Synonyms]

3-MATIDA
3 MATIDA,3MATIDA
α-Amino-5-carboxy-3-methyl-2-thiopheneaceticacid
2-Thiopheneacetic acid, α-amino-5-carboxy-3-methyl-
ALPHA-AMINO-5-CARBOXY-3-METHYL-2-THIOPHENEACETIC ACID
5-[amino(carboxy)methyl]-4-methylthiophene-2-carboxylic acid
[Molecular Formula]

C8H9NO4S
[MDL Number]

MFCD07783998
[MOL File]

518357-51-2.mol
[Molecular Weight]

215.23
Chemical PropertiesBack Directory
[storage temp. ]

Store at +4°C
[solubility ]

Soluble to 100 mM in 1eq. NaOH and to 50 mM in DMSO
[form ]

Powder
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

3-MATIDA is a potent mGluR-1 antagonist.
[Definition]

ChEBI: 5-[amino(carboxy)methyl]-4-methyl-2-thiophenecarboxylic acid is an alpha-amino acid.
[Biological Activity]

Potent metabotropic glutamate mGlu 1 receptor antagonist (IC 50 = 6.3 μ M at rat mGlu 1a ). Displays ≥ 40-fold selectivity over other receptors: mGlu 5 , mGlu 2 , mGlu 4a (IC 50 > 300 μ M), NMDA and AMPA (IC 50 = 250 μ M). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro . Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo .
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