ChemicalBook--->CAS DataBase List--->634175-34-1

634175-34-1

634175-34-1 Structure

634175-34-1 Structure
IdentificationBack Directory
[Name]

8-ethyl-5-oxo-2-[4-[[3-(trifluoromethyl)phenyl]carbamothioyl]piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acid
[CAS]

634175-34-1
[Synonyms]

ML328
8-ethyl-5-oxo-2-[4-[[3-(trifluoromethyl)phenyl]carbamothioyl]piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acid
Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-[4-[thioxo[[3-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-
[Molecular Formula]

C22H21F3N6O3S
[MOL File]

634175-34-1.mol
[Molecular Weight]

506.5
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 25 mg/mL (49.36 mM);Ethanol: Insoluble
[Water Solubility ]

Water: Insoluble
Spectrum DetailBack Directory
[Spectrum Detail]

8-ethyl-5-oxo-2-[4-[[3-(trifluoromethyl)phenyl]carbamothioyl]piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acid(634175-34-1)1HNMR
Hazard InformationBack Directory
[Biological Activity]

CID-1517823 (ML328) is a potent and selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases, with IC50s of 1.0 and 4.8 μM.
[References]

[1] Bannister TD, et al. 2012 Dec 17 [updated 2013 Apr 5]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
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