| Identification | Back Directory | [Name]
RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT | [CAS]
66983-94-6 | [Synonyms]
1-(5-O-Phosphono-β-D-ribofuranosyl)-
RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT
Ribavirin 5'-Monophosphate DilithiuM Salt (90%) | [Molecular Formula]
C17H19Li2N4O9P | [MDL Number]
MFCD04039674 | [MOL File]
66983-94-6.mol | [Molecular Weight]
468.21 |
| Chemical Properties | Back Directory | [Appearance]
Solid | [Melting point ]
220°C dec. | [storage temp. ]
-20°C Freezer | [solubility ]
Aqueous Acid (Slightly), Water (Slightly, Sonicated) | [form ]
Solid | [color ]
Off-White to Pale Beige | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
Solid | [Uses]
A metabolite of Ribavirin. | [Uses]
Used as an antiviral agent | [Description]
Ribavirin 5''-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5''-monophosphate. | [storage]
Store at -20°C |
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