ChemicalBook--->CAS DataBase List--->68630-75-1

68630-75-1

68630-75-1 Structure

68630-75-1 Structure
IdentificationBack Directory
[Name]

BUSERELIN
[CAS]

68630-75-1
[Synonyms]

Fuset
hoe766
EstoMal
Itorelin
Suprecur
hoe766mp
SupreMon
Buserecur
Suprafact
Suprecur-MP
buserelinacetate
BUSERELIN USP/EP/BP
Buserelina(acetate)
Buserelin Acetate, >99%
Buserelin?Acetate impurity
Buserelin acetate, Ph. Eur.
Buserelin acetate [USAN:JAN]
Buserelin Acetate, Buserelina
Buserelin for NMR identification
Buserelin for peak identification
Buserelin for NMR identification CRS
Buserelin for peak identification CRS
(DES-GLY10,D-SER(TBU)6,PRO-NHET9)-LHRH
des-gly10-[d-ser[t-bu]6]-lh-rh ethylamide
PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET
P-GLU-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET
9-(n-ethyl-l-prolinamide)-10-deglycinamide,monoacetate(salt)
6-(o-(1,1-dimethylethyl)-d-serine)-luteinizinghormone-releasingfactor(pig
pGlu-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NHEt, des-Gly10-[D-Ser[t-Bu]6]-LH-RH ethylamide
6-[O-(1,1-DiMethylethyl)-D-serine]-9-(N-ethyl-L-prolinaMide)-1-9-luteinizing HorMone-releasing Factor Monoacetate
1-9-Luteinizing hormone-releasing factor (swine), 6-O-(1,1-dimethylethyl)-D-serine-9-(N-ethyl-L-prolinamide)-, monoacetate (salt)
[EINECS(EC#)]

636-185-5
[Molecular Formula]

C62H90N16O15
[MDL Number]

MFCD01716229
[MOL File]

68630-75-1.mol
[Molecular Weight]

1299.5
Chemical PropertiesBack Directory
[Melting point ]

186-188°C
[storage temp. ]

-20°C
[solubility ]

DMSO (Slightly), Methanol (Slightly), Water (Slightly)
[form ]

Solid
[color ]

White to Off-White
[Stability:]

Hygroscopic
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

60
[Safety Statements ]

53-22-36/37/39-45
[WGK Germany ]

3
[RTECS ]

OK6370000
Hazard InformationBack Directory
[Description]

Buserelin acetate is a potent analog of the hypothalamic hormone, luteinizing hormone-releasing hormone (LH-RH). Chronic administration of higher doses of buserelin desensitizes the pituitary, resulting in a decreased production of luteinizing hormone (LH), follicle stimulating hormone (FSH), and eventually sex steroids (testosterone in males and estradiol in females). Initial approval is for use in achieving medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of endometriosis, leiomyoma, precocious puberty, advanced breast cancer and infertility.
[Chemical Properties]

White Solid
[Originator]

Hoechst AG (W. Germany)
[Uses]

Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal).
[Definition]

ChEBI: Buserelin acetate is an organic molecular entity.
[Brand name]

Suprefact (Hoechst-Roussel).
[Biochem/physiol Actions]

Buserelin is an LH-RH agonist.
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