| Identification | Back Directory | [Name]
pipradrol hydrochloride | [CAS]
71-78-3 | [Synonyms]
Gerodyl
MRD 108
Pipralon
Piridrol
Pyridrol
Meratran
Pyridrole
a-Pipradol
Pipradol hydrochloride
Pyridrol hydrochloride
Pepradrol hydrochloride
pipradrol hydrochloride
KIFIYUHFHGSNHL-UHFFFAOYSA-N
a-(2-Piperidyl)benzhydrol Hydrochloride
diphenyl(2-piperidyl)methanol hydrochloride
Diphenyl(piperidin-2-yl)methanol hydrochloride
a,a-Diphenyl-2-piperidinemethanol Hydrochloride | [EINECS(EC#)]
200-764-7 | [Molecular Formula]
C18H21NO.ClH | [MOL File]
71-78-3.mol | [Molecular Weight]
303.831 |
| Chemical Properties | Back Directory | [Melting point ]
298-300?C | [storage temp. ]
Controlled Substance, -20°C Freezer | [solubility ]
DMSO: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 0.5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Controlled substance (stimulant). CNS stimulant | [Description]
Pipradrol is a mild stimulant containing a piperidine ring. Once used as a treatment for obesity and dementia, pipradrol is now regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications. | [Originator]
Alertonic ,Adcock Ingram Ltd. | [Definition]
ChEBI: Pipradrol hydrochloride is a diarylmethane. | [Manufacturing Process]
A mixture of 48 g (0.167 mole) of α,α-diphenyl-2-pyridinemethanol hydrochloride (Emraert et al., Ber. 72B, 1188 (1939); 74B, 714 (1940), 160 ml of ethanol, and 3 0.5 g of Adams' platinum catalyst was shaken under an initial hydrogen pressure of 60 pounds. The theoretical amount of hydrogen was absorbed in 5 hours. The reaction mixture was refluxed, diluted with enough water to dissolve all the white solid, and filtered hot from the catalyst. The filtrate was cooled and filtered; yield of 38 g of α,α-diphenyl-alpha-(2piperidyl)methanol white product melting at 308-309°C with decomposition.
A mixture of 3.5 grams (0.013 mole) of the above α,α-diphenyl-alpha-(2piperidyl)methanol, 4 g (0.05 mole) of formaldehyde (37%), and 6 grams (0.1 mole) of formic acid was refluxed for 2 days. The reaction mixture was treated with 1.3 g (0.013 mole) of conc. hydrochloric acid and vacuum distilled on the steam bath. The residue was recrystallized from butanone to give the α,αdiphenyl-alpha-(2-piperidyl)methanol hydrochloride which melted at 228229°C (dec.). | [Brand name]
Meratran (Marion Merrell Dow). | [Therapeutic Function]
Central stimulant |
| Safety Data | Back Directory | [Safety Profile]
Poison by ingestion,
subcutaneous, intravenous, and
intraperitoneal routes. When heated to
decomposition it emits very toxic fumes of
HCl and NOx. |
|