| Identification | Back Directory | [Name]
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE | [CAS]
85416-75-7 | [Synonyms]
CS-1181
(?)-Rolipram
(-)-Rolipram
(S)-(+)-ROLIPRAM
(R)-(-)-ROLIPRAM
Rolipram (R)-(-)-
(R)-(-)-Rolipram
(R)-ROLIPRAM;(-)-ROLIPRAM
4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone
(4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
(R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
(4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
(4R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one
2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)- | [Molecular Formula]
C16H21NO3 | [MDL Number]
MFCD03093861 | [MOL File]
85416-75-7.mol | [Molecular Weight]
275.34 |
| Chemical Properties | Back Directory | [Melting point ]
132.0 to 136.0 °C | [Boiling point ]
472.7±45.0 °C(Predicted) | [density ]
1.155±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
White to off-white solid. | [pka]
16.02±0.40(Predicted) | [color ]
Off-White |
| Hazard Information | Back Directory | [Uses]
R-enantiomer of rolipram which is more active at inhibition of PDE IV, Ki=06 μM. 10-fold more active than S-rolipram at inhibition of PDE IV. Inhibits antigen-induced contraction of guinea-pig colonic smooth muscle, EC50=0.1 μM. | [Definition]
ChEBI: (-)-rolipram is the (R)-enantiomer of rolipram. It is an enantiomer of a (+)-rolipram. | [Biological Activity]
More active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ); 2-10-fold more potent than the S-(+) enantiomer ((4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one ). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ . | [storage]
Store at -20°C |
|
| Company Name: |
Ark Pharm, Inc.
|
| Tel: |
847-367-3680 |
| Website: |
www.arkpharminc.com |
|