1000578-26-6
1000578-26-6 结构式
基本信息
(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
2-Naphthalenamine, 1,2,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-, (2S)-
常见问题列表
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Human 5-HT 7 Receptor 0.83 nM (IC 50 ) |
Human 5-HT 7 Receptor 0.6 nM (Ki) |
5-HT 1A Receptor 89.7 nM (Ki) |
5-HT 1B Receptor 490 nM (Ki) |
5-HT 1D Receptor 6.6 nM (Ki) |
5-HT 5 Receptor 98.5 nM (Ki) |
The proliferation of T-cell from parachlorophenylalanine-treated mice is significantly reduced, addition of AS19 (1 μM) completely restores T-cell proliferation after 48 hours.
AS19 (0.5-10 mg/kg; subcutaneous injection; for 24 hours; male Wistar rats) treatment improves memory consolidation in an autoshaping Pavlovian/instrumental learning task.
| Animal Model: | Male Wistar rats (12-week-old) with autoshaping Pavlovian/instrumental learning task |
| Dosage: | 0.5 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg |
| Administration: | Subcutaneous injection; for 24 hours |
| Result: | Enhanced memory formation in an autoshaping Pavlovian/instrumental learning task. |