1146963-51-0

中文名称 N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE

英文名称 J 147

CAS 1146963-51-0

分子式 C18H17F3N2O2

分子量 350.33

MOL 文件 1146963-51-0.mol

更新日期 2024/05/11 09:43:49

1146963-51-0 结构式

基本信息物理化学性质图谱信息 J-147价格(试剂级) 常见问题列表

基本信息

中文别名

2,2,2-三氟乙酸 1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亚甲基]酰肼

英文别名

J 147
CS-1446
J147-API
J147/J-147
J-147?, >98%
Nootropic J147
J 147(Nootropic Powder)
N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE
(E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide
2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点412.8±55.0 °C(Predicted)

密度1.18±0.1 g/cm3(Predicted)

储存条件Sealed in dry,Room Temperature

溶解度DMSO:68.0(Max Conc. mg/mL);194.1(Max Conc. mM)

酸度系数(pKa)0.80±0.50(Predicted)

形态粉末

InChIInChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3

InChIKeyHYMZAYGFKNNHDN-UHFFFAOYSA-N

SMILESC(N(C1=CC=C(C)C=C1C)N=CC1=CC=CC(OC)=C1)(=O)C(F)(F)F

图谱信息

N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE(1146963-51-0)核磁图(¹HNMR)

J-147价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-13779	N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147	1146963-51-0	5mg	500元
2024/04/30	HY-13779	N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147	1146963-51-0	10mM * 1mLin DMSO	550元
2024/04/30	HY-13779	N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147	1146963-51-0	10mg	700元

常见问题列表

生物活性

J-147 是一种特别有效的，具有口服活性的神经保护剂，可增强认知能力。J-147 可透过血脑屏障 (BBB)。J-147 抑制单胺氧化酶 B (MAO B) 和多巴胺转运体 (dopamine transporter)，EC50 分别为 1.88 μM 和 0.649 μM。J-147 有潜力用于阿尔茨海默氏症 (AD) 的研究。

靶点

MAO B; Dopamine transporter

体外研究

J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC ₅₀ value range of 0.06-0.115 μM) .

体内研究

J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.
The half life (t _1/2 ) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).

Animal Model:	24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls
Dosage:	200 ppm
Administration:	The diet was prepared by the addition of 200ppm; 6 months
Result:	While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147.