1219707-39-7
中文名称
DELPAZOLID
英文名称
Delpazolid
CAS
1219707-39-7
分子式
C14H17FN4O3
分子量
308.31
MOL 文件
1219707-39-7.mol
更新日期
2024/04/22 14:25:57
1219707-39-7 结构式
基本信息
中文别名
化合物DELPAZOLID 英文别名
CS-2617Delpazolid
LCB01-0371
Delpazolid (LCB01-0371)
DELPAZOLID
LCB01-0371
LCB 01-0371
LCB-01-0371
LCB010371
LCB 010371
LCB-010371
(R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one
(5R)-3-[4-(5,6-Dihydro-1-methyl-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl]-5-(hydroxymethyl)-2-oxazolidinone
2-Oxazolidinone, 3-[4-(5,6-dihydro-1-methyl-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl]-5-(hydroxymethyl)-, (5R)-
Delpazolid/(5R)-3-[4-(5,6-Dihydro-1-methyl-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl]-5-(hydroxymethyl)-2-oxazolidinone
物理化学性质
沸点481.8±55.0 °C(Predicted)
密度1.44±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO:30.0(Max Conc. mg/mL);97.3(Max Conc. mM)
酸度系数(pKa)14.05±0.10(Predicted)
形态结晶固体
应用领域
用途1
一种新型的恶唑烷酮类抗生素，能抑制MSSA和MRSA的生长，对它们的MIC90值为2μg/mL。Delpazolid is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic infections in mice was also evaluated. LCB01-0371 was more active than linezolid against these systemic infections. LCB01-0371 showed bacteriostatic activity against Staphylococcus aureus.