1357289-29-2
中文名称
度鲁特韦杂质6
英文名称
Dolutegravir Impurity 6
CAS
1357289-29-2
分子式
C20H19F2N3O5
分子量
419.38
MOL 文件
1357289-29-2.mol
更新日期
2024/05/07 22:38:26
1357289-29-2 结构式
基本信息
中文别名
度鲁特韦杂质6度鲁特韦杂质B
杜鲁特韦杂质3
多替拉韦杂质12
度鲁特韦杂质42
多替拉韦RR异构体
度鲁特韦非对映异构体1
DOLUTEGRAVIR杂质B
英文别名
Dolutegravir RR IsomerDolutegravir Impurity 6
Doultegravirr RR Isomer
Dolutegravir Impurity 42
(4R,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aR)-
所属类别
分析化学：药典标准品和杂质标准品应用领域
用途一
Dolutegravir RR Isomer is an isomer of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.