返回ChemicalBook首页>CAS数据库列表>150145-89-4

150145-89-4

中文名称 (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
英文名称 (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
CAS 150145-89-4
分子式 C10H11NO4
分子量 209.2
MOL 文件 150145-89-4.mol
150145-89-4 结构式 150145-89-4 结构式

基本信息

中文别名
(ALPHAS)-ALPHA-氨基-4-羧基-ALPHA-甲基-苯乙酸
英文别名
(S)-MCPG
(+)-MCPG
(alphaS)-alpha-Amino-4-Carbo
(+)-α-methyl-4-carboxyphenylglycine
(S)-α-Methyl-4-carboxyphenylglycine
(S)-ALFA-METHYL-4-CARBOXYPHENYLGLYCINE
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
(+)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
4-((1S)-1-AMINO-1-CARBOXYETHYL)BENZOIC ACID
(S)-alpha-Methyl-4-carboxyphenylglycine(S)-MCPG
所属类别
生物化工:甘氨酸类衍生物

物理化学性质

储存条件Store at RT
溶解度0.1 M NaOH: 15 mg/mL
溶解度0.1MNaOH:15 mg/mL
形态solid
颜色白色至灰白色
旋光性 (optical activity)[α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.)

安全数据

安全说明24/25
WGK Germany3
WGK Germany3
海关编码29224985
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-100406(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
(S)-MCPG
150145-89-45mg800元
2024/04/30HY-100406(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
(S)-MCPG
150145-89-410mg1100元
2024/04/30HY-100406(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
(S)-MCPG
150145-89-425mg2300元

常见问题列表

生物活性
(S)-MCPG ((+)-MCPG) 是一种有效的 I/II 类代谢型谷氨酸受体 (mGluRs) 拮抗剂,是 (RS)-MCPG (HY-100371) 的活性异构体。(S)-MCPG 可用于 mGluRs 在空间学习中的作用研究。
靶点

mGluR

体外研究

(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures.

体内研究

MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze.

Animal Model: Male Lister-Hooded rats in the learning of the Morris water maze
Dosage: 20 μg
Administration: Intraventricular injection; 20 μg; 4 days
Result: Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
"150145-89-4" 相关产品信息
73401-74-8 22038-86-4 27298-98-2 13227-01-5 146669-29-6