15966-93-5
中文名称
VEGFR2 KISE INHIBITOR I
英文名称
VEGFR2 Kinase Inhibitor I
CAS
15966-93-5
分子式
C18H18N2O3
分子量
310.35
MOL 文件
15966-93-5.mol
更新日期
2024/05/07 11:49:58
15966-93-5 结构式
基本信息
中文别名
RAMUCIRUMAB ( 雷莫芦单抗 )化合物VEGFR2 KINASE INHIBITOR I
2,4-二甲基-5-((2-氧吲哚-3-亚甲基)甲基)-1H-吡咯-3-羧酸乙酯
英文别名
SU5408VEGFR2 TK Inhibitor
SU 5408
SU-5408
SU5408
VEGFR2 KISE INHIBITOR I
VEGFR2 Kinase Inhibitor I
VEGFR2 kinase inhibitor I(SU-5408)
1H-Pyrrole-3-carboxylic acid, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-, ethyl ester
物理化学性质
沸点571.4±50.0 °C(Predicted)
密度1.271±0.06 g/cm3(Predicted)
储存条件Sealed in dry,Store in freezer, under -20°C
溶解度DMF: 1 mg/ml; DMSO: 1 mg/ml
酸度系数(pKa)12.40±0.20(Predicted)
形态结晶固体
VEGFR2 KISE INHIBITOR I价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-103002 | VEGFR2 KISE INHIBITOR I SU5408 | 15966-93-5 | 1 mg | 800元 |
| 2024/04/30 | HY-103002 | VEGFR2 KISE INHIBITOR I SU5408 | 15966-93-5 | 5mg | 2400元 |
| 2024/04/30 | HY-103002 | VEGFR2 KISE INHIBITOR I SU5408 | 15966-93-5 | 10mM * 1mLin DMSO | 2640元 |
常见问题列表
生物活性
SU5408 (VEGFR2 Kinase Inhibitor I)是一种有效、选择性 VEGFR2 Kinase抑制剂，IC50为70 nM。靶点
| Target | Value |
|
VEGFR2
(Cell-free assay) | 70 nM |
体外研究
3-Substituted indolin-2-ones have been designed and synthesized as a novel class of tyrosine kinase inhibitors which exhibit selectivity toward different receptor tyrosine kinases (RTKs). These compounds have been evaluated for their relative inhibitory properties against a panel of RTKs in intact cells. SU5408 (VEGFR2 Kinase Inhibitor I) is found to be the most potent and selective VEGFR2 inhibitor among the compounds. SU5408 (VEGFR2 Kinase Inhibitor I) shows little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC 50 >100 µM).