1863916-88-4
中文名称
多替拉韦杂质4
英文名称
Dolutegravir 2-Desfluoro Impurity
CAS
1863916-88-4
分子式
C20H20FN3O5
分子量
401.39
MOL 文件
1863916-88-4.mol
更新日期
2024/05/13 17:04:01
1863916-88-4 结构式
基本信息
中文别名
多替拉韦杂质4度鲁特韦杂质G
杜鲁特韦杂质1
度鲁特韦钠杂质F
多替拉韦杂质50
多替拉韦杂质 47
英文别名
4-Fluoro DolutegravirDolutegravir Impurity G
Dolutegravir Impurity 50
Dolutegravir Impurity 47
Dolutegravir 2-Desfluoro Impurity
(4R,12aS)-N-(4-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-/Dolutegravir impurity
Dolutegravir impurity 4/Defluoro Dolutegravir/(4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
所属类别
分析化学：药典标准品和杂质标准品应用领域
用途一
Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.