2189-80-2
中文名称
乙酰蒲公英萜醇
英文名称
taraxerol acetate
CAS
2189-80-2
分子式
C32H52O2
分子量
468.77
MOL 文件
2189-80-2.mol
更新日期
2023/10/07 10:44:27
2189-80-2 结构式
基本信息
中文别名
醋酸蒲公英霜蒲公英萜醇乙酯
蒲公英萜醇乙酸酯
蒲公英萜醇乙酯对照品
蒲公英萜醇乙酯标准品
乙酰蒲公英萜醇,蒲公英萜醇乙酯
英文别名
araxerolacetateAcetyl taraxerol
Taraxenol acetate
Taraxerol monoacetate
Friedoolean-14-en-3-yl acetate
D-Friedoolean-14-en-3beta-yl acetate
D-Friedoolean-14-en-3-ol, acetate, (3beta)-
27-Norolean-14-en-3-ol, 13-methyl-, 3-acetate, (3β,13α)-
(3beta,13alpha)-13-Methyl-27-norolean-14-en-3-ol 3-acetate
所属类别
天然产物：萜类物理化学性质
外观性状白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于蒲公英。
熔点303-305℃
沸点505.1±49.0 °C(Predicted)
密度1.02
储存条件-20°C储存
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
形态粉末
常见问题列表
生物活性
Taraxerol acetate 是 COX-1 和 COX-2 抑制剂， IC50 值分别为 116.3 μM 和 94.7μM。Taraxerol acetate 具有抗癌作用并诱导细胞凋亡(apoptosis)。靶点
|
COX-1 116.3 μM (IC 50 ) |
COX-2 94.7 μM (IC 50 ) |
体外研究
Taraxerol acetate(10-150 µM; 24 or 48 hours) induces a dose- and time-dependent cytotoxic effects in the U87 cells, exhibits IC 50 values of 34.2 and 28.4 µM, at 24 and 48 h, respectively. Taraxerol acetate(10, 50 and 150 µM; 24 hours) induces cell apoptosis, the percentage of apoptotic cells increased from 7.3% in the control cells, to 16.1, 44.1 and in the 10, 50 and 150 µM taraxerol acetate-treated cells, respectively. Furthermore, taraxerol acetate treatment led to sub-G1 cell cycle arrest with a corresponding decrease in the number of S-phase cells.