22338-71-2
中文名称
远志酸
英文名称
Polygalacic acid
CAS
22338-71-2
分子式
C30H48O6
分子量
504.7
MOL 文件
22338-71-2.mol
更新日期
2024/05/05 03:01:13
22338-71-2 结构式
基本信息
中文别名
远志酸远志酸(标准品)
远志酸, 来源于远志
毛果一枝黄花皂苷元G
远志酸,毛果一枝黄花皂苷元G
英文别名
PolygalacicPolygalacic acid
Virgaureagenin G
Polygalacic acid, >=98%
(4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic acid, 98%, from Polygala tenuifolia Willd.
(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-
Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
所属类别
生物化工：提取物物理化学性质
熔点300-305 °C (sublm)
沸点638.1±55.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
储存条件4°C, protect from light
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系数(pKa)4.41±0.70(Predicted)
形态粉末
远志酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-N0801 | 远志酸 Polygalacic acid | 22338-71-2 | 1mg | 1100元 |
| 2024/04/30 | S9386 | 远志酸 Polygalacic acid | 22338-71-2 | 1mg | 1204.48元 |
| 2024/04/30 | HY-N0801 | 远志酸 Polygalacic acid | 22338-71-2 | 5mg | 3200元 |
常见问题列表
生物活性
Polygalacic acid 是从远志属植物（Polygala paenea L.）分离出的三萜类四羟酸。Polygalacic acid (0-100μM; 24h) 可以显著降低 MMP-3、MMP-9、MMP-13 和 COX-2 的mRNA表达，这些因子的表达由IL-1β诱导可显著增加，并呈现出剂量依赖性。体外研究
Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid.
RT-PCR
| Cell Line: | Chondrocyte cells |
| Concentration: | 50 μM; 100 μM |
| Incubation Time: | 24 hours |
| Result: | Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. |
Western Blot Analysis
| Cell Line: | Chondrocyte cells |
| Concentration: | 50 μM; 100 μM |
| Incubation Time: | 6 hours |
| Result: | Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes. |