229961-08-4
中文名称
ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
英文名称
H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
CAS
229961-08-4
分子式
C64H103N21O14S
分子量
1422.7
MOL 文件
229961-08-4.mol
更新日期
2024/06/02 19:54:15
229961-08-4 结构式
基本信息
中文别名
RF-12 英文别名
APELIN 12RPRLSHKGPMPF
Apelin-12,(Des-Gln1)-Apelin-13
APELIN-12 (HUMAN, BOVINE, MOUSE, RAT)
ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
PREPROAPELIN (66-77) (HUMAN, BOVINE, MOUSE, RAT)
(DES-GLN1)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)
H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
APELIN PRECURSOR (66-77) (HUMAN, BOVINE, MOUSE, RAT)
Apelin-12 (human, bovine, mouse, rat) H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
常见问题列表
生物活性
Apelin-12 是多肽中最有效的 C 端片段之一，对孤儿受体 APJ 受体具有很高的亲和力。Apelin-12 参与体液平衡的调节和摄食的中枢控制。Apelin-12 阻断HIV-1通过 APJ 受体进入。Apelin-12 具有神经保护作用。体外研究
Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse.
Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents.
Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs.