2746-81-8
中文名称
氟奋乃静庚酸酯
英文名称
fluphenazine O-enantate
CAS
2746-81-8
分子式
C29H38F3N3O2S
分子量
549.698
MOL 文件
2746-81-8.mol
2746-81-8 结构式
基本信息
中文别名
氟奋乃静庚酸酯癸氟奋乃静杂质C(EP)
氟奋乃静庚酸盐 EP标准品
氟奋乃静癸酸酯杂质C (EP)
癸氟奋乃静杂质3(癸氟奋乃静EP杂质C)
英文别名
moditen enanthatefluphenazine O-enantate
Fluphenazine enantate CRS
Fluphenazine Decanoate Impurity 3 (Fluphenazine Decanoate EP Impurity C)
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate
2-[4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl heptanoate
enanthic acid 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl ester
Heptanoic acid, 2-4-3-2-(trifluoromethyl)-10H-phenothiazin-10-ylpropyl-1-piperazinylethyl ester
所属类别
化学试剂：肼物理化学性质
熔点184.5°C
沸点629.4±55.0 °C(Predicted)
密度1.1661 (estimate)
溶解度Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.
酸度系数(pKa)7.32±0.10(Predicted)
形态neat
常见问题列表
生物活性
Fluphenazine enanthate 是第一种长效抗精神病药物，用于研究精神分裂症。体内研究
Fluphenazine enanthate (2,4, 8 mg/kg; IM) significant inhibition of the avoidance performance is observed as long as 16, 23, and 28 days, respectively.
Fluphenazine enanthate (8 mg/kg) drinking behavior is almost completely suppressed for 24 hours immediately following the administration.
Fluphenazine enanthate (8 mg/kg) produces transient body weight Iosses in the rats.
| Animal Model: | Fifty-four male adult rats of Wistar strain |
| Dosage: | 2, 4, and 8 mg/kg |
| Administration: | Index medicus (IM ) |
| Result: | Three doses of Fluphenazine enanthate significant inhibition of the avoidance performance was observed as long as 16, 23, and 28 days, respectively. |