2889-31-8

中文名称 2H4]-D,L-2-羟基戊二酸

英文名称 C02630

CAS 2889-31-8

分子式 C5H8O5

分子量 148.11

MOL 文件 2889-31-8.mol

2889-31-8 结构式

基本信息物理化学性质常见问题列表

基本信息

英文别名

C02630
2-hydroxyglutarate
α-Hydroxyglutaric Acid
alpha-hydroxyglutarate
a-Hydroxyglutaric Acid
2,3-Dideoxypentaric Acid
DL-2-Hydroxyglutaric Acid

物理化学性质

熔点98-100 °C(Solv: ethyl acetate (141-78-6))

沸点394.2±27.0 °C(Predicted)

密度1.508±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml

酸度系数(pKa)3.67±0.10(Predicted)

常见问题列表

生物活性

α-Hydroxyglutaric acid (2-Hydroxyglutarate) 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid 是多种 α-酮戊二酸依赖性双加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。

体外研究

Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively.
α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases.
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin.