301326-22-7

中文名称 1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺

英文名称 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

CAS 301326-22-7

分子式 C19H19N5O

分子量 333.387

MOL 文件 301326-22-7.mol

更新日期 2024/05/30 08:55:42

301326-22-7 结构式

基本信息物理化学性质安全数据常见问题列表图谱信息 1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺价格(试剂级)

基本信息

中文别名

化合物CH 223191
1-甲基-N-[2-甲基-4-[(2-甲基苯基)偶氮]苯基]-1H-吡唑-5-甲酰胺
1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺

英文别名

CS-2720
CH 223191
AhR Antagonist
CH223191
CH 223191
AhR Antagonist - CAS 301326-22-7 - Calbiochem
2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-c
2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide
1-Methyl-N-[2-methyl-4-[(2-methylphenyl)azo]phenyl]-1H-pyrazole-5-carboxamide
(E)-1-methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamide
2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide

所属类别

生物化工：AhR 拮抗剂

物理化学性质

熔点>164°C (dec.)

沸点469.4±45.0 °C(Predicted)

密度1.20±0.1 g/cm3(Predicted)

储存条件2-8°C

储存条件Store at +4°C

溶解度二甲基亚砜：≥20mg/mL

酸度系数(pKa)12.98±0.70(Predicted)

形态粉末

颜色橙褐色

稳定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

InChIKeyLKTNEXPODAWWFM-GHVJWSGMSA-N

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302

防范说明P264-P270-P301+P312-P330-P501

危险品标志Xn

危险类别码22

安全说明22

WGK Germany3

常见问题列表

生物活性

CH-223191是一种有效的特定aryl hydrocarbon receptor (AhR)拮抗剂，IC50为30 nM。

体外研究

CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation.

体内研究

CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice.

图谱信息

1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺(301326-22-7)核磁图(¹HNMR)

1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-12684	1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺 CH-223191	301326-22-7	5mg	600元
2024/04/30	HY-12684	1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺 CH-223191	301326-22-7	10mg	1020元
2024/04/30	HY-12684	1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺 CH-223191	301326-22-7	50mg	3180元