4533-39-5
4533-39-5 结构式
基本信息
中文别名
二胺硝吖啶 英文别名
Nitracrine3-(dimethylamino)propyl-(1-nitroacridin-9-yl)amine
N',N'-dimethyl-N-(1-nitroacridin-9-yl)propane-1,3-diamine
1,3-Propanediamine, N1,N1-dimethyl-N3-(1-nitro-9-acridinyl)-
物理化学性质
熔点134-135°
沸点462.71°C (rough estimate)
密度1.2155 (rough estimate)
折射率1.6700 (estimate)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)pKa1 6.45; pKa2 8.8(at 25℃)
常见问题列表
生物活性
Nitracrine 抑制 RNA 合成 (RNA synthesis)，共价，可逆地与 DNA 结合，在体内与 DNA 形成共价加合物。Nitracrine 是 1-nitroacridine 衍生物，一种有效的体外缺氧选择性药物和抗肿瘤药物。Nitracrine 具有细胞毒性。体外研究
Nitracrine (2 μM; 1 hour) causes death of 50% of human erythroleukemia K562 cells under illumination for 48 min. While it is 8.5 hours for Nitracrine on the dark.
Nitracrine has LD50s of 0.23 μM, 0.6 μM, 0.16 μM in P388 cell, NIH3T3 cell, and K562 cells under illumination after 1 hour of cells incubation, respectively.
Cell Cytotoxicity Assay
| Cell Line: | Human erythroleukemia K562 cells |
| Concentration: | 2 μM |
| Incubation Time: | 1 hour |
| Result: | Death of 50% of human erythroleukemia K562 cells were achieved under illumination for 48 min. |