481-42-5
中文名称
兰雪醌
英文名称
PLUMBAGIN
CAS
481-42-5
分子式
C11H8O3
分子量
188.18
MOL 文件
481-42-5.mol
更新日期
2024/05/07 08:44:04
481-42-5 结构式
基本信息
中文别名
兰雪醌矾松素
矶松素
白花丹醌
白花丹精
白花丹素
石苁蓉萘醌
石苁溶萘醌
白花丹醌/兰雪醌
白花丹醌(白花丹素)
英文别名
PLUMBAGINPLUMBAGAN
plumbapin
plumbagone
NSC 236613
NSC 688284
Plumbagine
Ophioxylin
Plumbagin,95%
PLUMBAGIN(RG)
所属类别
化学试剂：双环化合物物理化学性质
熔点76-78 °C(lit.)
沸点283.17°C (rough estimate)
密度1.354
折射率1.6310 (estimate)
储存条件−20°C
溶解度在热甲醇中有非常微弱的浑浊
酸度系数(pKa)6.70±0.20(Predicted)
形态晶体或结晶粉末
颜色橙色
Merck7538
稳定性吸湿性
LogP2.450 (est)
安全数据
警示词危险
危险性描述H301-H315-H319-H335
危险品标志T
危险类别码25-34-36/37/38
危险品运输编号UN 2923 8/PG 2
WGK Germany3
RTECS号QL8500000
Hazard NoteToxic
危险等级6.1(a)
包装类别II
海关编码29146990
毒性LD50 i.p. in mice: ~0.015 g/kg (Debray)
常见问题列表
生物活性
Plumbagin (2-Methyljuglone) 是从 Plumbago zeylanica L 中得到的萘醌类物质，具有抗肿瘤、抗增殖活性。体外研究
Plumbagin (0, 5, 10, and 15 μM) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1 and LNCaP, in a dose-dependent manner.
Plumbagin (5, 20 μM) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells.
Apoptosis Analysis
| Cell Line: | DU145, CWR22rv1, LNCaP and RWPE-1 cells |
| Concentration: | 0, 5, 10, and 15 μM |
| Incubation Time: | 24 hours |
| Result: | Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed no effect on RWPE-1 cells at up to 20 μM. |
体内研究
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nude mice.
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKCε, suppresses JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice.
| Animal Model: | Male athymic nude mice bearing DU145 cells |
| Dosage: | 2 mg/kg |
| Administration: | I.P. after 3 days post cell implantation, five days a week. |
| Result: | Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice. |