5189-11-7
![5189-11-7 结构式](/CAS/GIF/5189-11-7.gif)
基本信息
苯噻啶苹果酸盐
苯噻啶苹果酸酯
双氯芬酸苹果酸盐
PIZOTIFEN苹果酸
苯噻啶苹果酸盐(偏头痛)
9,10-二氢-4-(1-甲基哌啶-4-亚基)-4H-苯并[4,5]环庚烷并[1,2-b]噻吩苹果酸盐 (1:1)
sanomtgran
bc105malate
litecmalate
malate(1:1)
Pizotifen Mala
Einecs 225-970-4
PIZOTIFEN MALATE
sandomygranmalate
PIZOTYLINE MALATE
物理化学性质
常见问题列表
5-HT 2A Receptor
|
5-HT 1C Receptor
|
Pizotifen malate (BC-105 malate) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Pizotifen is an antidepresent 5-HT 2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation.
The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group.