53174-06-4

中文名称 (S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸

英文名称 (S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

CAS 53174-06-4

分子式 C14H18O4

分子量 250.29

MOL 文件 53174-06-4.mol

53174-06-4 结构式

基本信息物理化学性质安全数据应用领域图谱信息常见问题列表

基本信息

中文别名

(S)-()-6-羟基-2,5,7,8-四甲基色烷-2-羧酸
(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸

英文别名

Trolox (S)-Isomer
Trolox Impurity 2 (Trolox (S)-Isomer)
(S)-(-)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-C
(2S)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
(S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
(S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 98%
(S)-6-Hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
(S)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
(2S)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid
(2S)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2α-carboxylic acid

物理化学性质

熔点160 °C (dec.) (lit.)

沸点450.3±45.0 °C(Predicted)

密度1.219±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度Acetonitrile (Slightly), Chloroform (Slightly, Sonicated), Methanol (Slightly)

酸度系数(pKa)3.35±0.20(Predicted)

形态固体

颜色白色至浅米色

旋光性 (optical activity)[α]26/D 65°, c = 1.2 in ethanol

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H315-H319-H335

防范说明P261-P264-P271-P280-P302+P352-P305+P351+P338

危险品标志Xi

危险类别码36/37/38

安全说明26-37/39

WGK Germany3

应用领域

用途1

色满具有α-生育酚手性中心。

图谱信息

(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸(53174-06-4)红外图谱(IR)

常见问题列表

生物活性

(S)-Trolox 是维生素 E 的类似物，其中的植酸基链被羧基取代。(S)-Trolox 经常用作研究结构特征的模型化合物，以及作为评估抗氧化剂活性的标准。(S)-Trolox 具有有效而特定的神经保护和抗氧化作用。

体外研究

The neuroprotective efficacy of antioxidant molecules against iodoacetate (IAA) neurotoxicity in rat cerebellar granule cell (CGC) cultures is investigated. In the absence of MK-801, (S)-Trolox displays marginal neuroprotective effects. In the presence of MK-801 (10 μM), the neuroprotective efficacy of (S)-Trolox is greatly enhanced, giving rise to a recovery in MTT-reductase activity equivalent to 80–100% of control cultures. (S)-Trolox displays EC50 value of 78 μM. The fluorescence increase in IAA-stimulated DCFH-DA-loaded cultures is inhibited in a dose-dependent manner by the antioxidants (S)-Trolox with an IC50 value of 97 μM. The antioxidant (S)-Trolox demonstrate apotent and specific neuroprotective action in an in vitro model of neurodegeneration induced by inhibition of the glycolytic enzyme GAPDH.