66969-81-1
66969-81-1 结构式
基本信息
中文别名
硫大唑嗪硫达唑嗪
英文别名
BL-5111Tiodazosin
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[5-(methylthio)-1,3,4-oxadiazol-2-yl]carbonyl]piperazine
Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][5-(methylthio)-1,3,4-oxadiazol-2-yl]-
物理化学性质
沸点690.2±65.0 °C(Predicted)
密度1.50±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)6.52±0.50(Predicted)
常见问题列表
生物活性
Tiodazosin 是一种有效且有竞争性的突触后 α 肾上腺素能受体 (alpha adrenergic receptor) 拮抗剂。靶点
alpha adrenergic receptor
体外研究
Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA 2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response.