68027-15-6

中文名称 Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside

英文名称 Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside

CAS 68027-15-6

分子式 C47H76O17

分子量 913.1

MOL 文件 68027-15-6.mol

更新日期 2024/05/19 08:57:45

68027-15-6 结构式

基本信息物理化学性质应用领域 Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside价格(试剂级) 常见问题列表

基本信息

中文别名

白头翁皂苷D标准品
白头翁皂苷 D, BR
常春藤皂苷元3-O-Α-L-吡喃鼠李糖-(1→2)-Β-D-吡喃葡萄糖-(1→4)-Α-L-吡喃阿拉伯糖苷

英文别名

Pulsatilla saponin D, BR
Pulsatilla Saponin D (90%)
Pulsatilla saponin D (SB365)
Pulsatilla saponin D 68027-15-6
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
Olean-12-en-28-oic acid,3-[[O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl]oxy]-23-hydroxy-, (3b,4a)-
Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β,4α)-

所属类别

生物化工：激动剂抑制剂

物理化学性质

外观性状白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白头翁。

熔点239-241℃

沸点997.6±65.0 °C(Predicted)

密度1.40±0.1 g/cm3 (20 ºC 760 Torr)

储存条件Hygroscopic, -20°C Freezer, Under inert atmosphere

溶解度少许溶于甲醇、可溶于吡啶

酸度系数(pKa)4.63±0.70(Predicted)

形态固体

颜色白色至浅米色

应用领域

用途1

药理药效:抗菌，抗肿瘤，镇静，镇痛

用途2

白头翁皂苷D具有抗菌，抗肿瘤，镇静，镇痛的作用。

常见问题列表

生物活性

Pulsatilla saponin D (SB365) 可从 Pulsatilla koreana Nakai 根部分离得到，具有抗癌活性。

靶点

Target	Value
c-Met ()

体外研究

Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase.
Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells.
Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) .
Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF.
Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells.

Cell Cytotoxicity Assay

Cell Line:	A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells.
Concentration:	0.3 ng/mL to 10 μg/mL.
Incubation Time:	72 h.
Result:	Exhibited an ED ₅₀ value of 6.3 μg/mL for A-549 cells.

体内研究

Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model.

Animal Model:	2x2x2 mm ³ tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice.
Dosage:	6.4 mg/kg.
Administration:	Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day.
Result:	Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%).