68414-18-6

中文名称腺苷5'-二磷酸核糖钠

英文名称 ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT

CAS 68414-18-6

分子式 C15H22N5NaO14P2

分子量 581.3

MOL 文件 68414-18-6.mol

更新日期 2024/05/11 16:39:14

68414-18-6 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

二磷酸腺苷核糖
腺苷5'-二磷酸核糖钠

英文别名

adp-ribose
ADP ribose sodium
adenosine 5'-diphosphoribose sodium
ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT
Adenosine 5'-diphosphoribose sodium salt >=93%
ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE
ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT 2-HYDRATE
[[5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL] (2,3,4-TRIHYDROXY-5-OXOPENTYL) HYDROGEN PHOSPHATE,SODIUM

所属类别

有机原料：羧酸类化合物及衍生物

物理化学性质

储存条件-20°C

水溶解性Water : 125 mg/mL (215.04 mM)

InChIKeyMBPRZUBFEMLFGQ-UUIVKEFHSA-M

SMILESO[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,17,19,24,r|

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H315-H319-H335

防范说明P261-P264-P271-P280-P302+P352-P305+P351+P338

危险品标志Xi

危险类别码36/37/38

安全说明26-36

WGK Germany3

常见问题列表

生物活性

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 的代谢产物，也是一种最有效和最主要的细胞内 Ca2+ 渗透性阳离子 TRPM2 通道激活剂，还可以增强自噬 (autophagy)。

靶点

TRPM2 channel
Autophagy

体外研究

In mouse embryonic fibroblasts (MEFs), H ₂ O ₂ treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca ²⁺ elevation through extracellular Ca ²⁺ influx and (or) lysosomal Ca ²⁺ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca ²⁺ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.