69542-93-4
中文名称
匹伐加宾
英文名称
Pivagabine
CAS
69542-93-4
分子式
C9H17NO3
分子量
187.24
MOL 文件
69542-93-4.mol
更新日期
2023/03/20 15:41:23
69542-93-4 结构式
基本信息
中文别名
匹伐加宾4-新戊酰氨基丁酸
英文别名
TonergCXB 722
Pivagabine
PG 2 (pharmaceutical)
4-PivalaMidobutanoic acid
4-(Pivaloylamino)butanoic acid
N-trimethylacetyl-4-aminobutyric acid
4-(2,2-Dimethylpropionamido)butanoic acid
4-[(2,2-dimethylpropionyl)amino]butyric acid
Butanoic acid,4-[(2,2-diMethyl-1-oxopropyl)aMino]-
常见问题列表
生物活性
Pivagabine (CXB 722) 是具有神经调节活性的疏水性4-氨基丁酸衍生物。Pivagabine 能穿透大鼠的血脑屏障。Pivagabine 拮抗足部休克对大鼠脑内 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。体内研究
Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions.
| Animal Model: | Adult male Sprague-Dawley CD rats (200-250 g) |
| Dosage: | 200 mg/kg |
| Administration: | i.p.; twice a day for 4 days and 1 hour before killing on the 5th day |
| Result: | Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex. |