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71186-53-3

中文名称 5-羟基癸酸钠
英文名称 5-HYDROXYDECANOIC ACID SODIUM SALT
CAS 71186-53-3
分子式 C10H19NaO3
分子量 210.25
MOL 文件 71186-53-3.mol
71186-53-3 结构式 71186-53-3 结构式

基本信息

中文别名
化合物5-HYDROXYDECANOATE SODIUM
英文别名
5-HYDROXYDECANOATE NA
5-Hydroxydecanoate sodium
Sodium 5-hydroxydecanoate
5-HYDROXYDECANOIC ACID SODIUM
5-HYDROXYDECANOIC ACID SODIUM SALT
5-Hydroxydecanoic acid sodium salt,5-hydroxydecanoate sodium salt

物理化学性质

储存条件desiccated
溶解度H2O: soluble
形态solid
颜色white

安全数据

WGK Germany3
5-羟基癸酸钠价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/01/25HY-1366155-羟基癸酸钠
5-Hydroxydecanoate sodium
71186-53-325mg600元
2024/01/25HY-1366155-羟基癸酸钠
5-Hydroxydecanoate sodium
71186-53-310mM * 1mLin DMSO660元
2024/01/25HY-1366155-羟基癸酸钠
5-Hydroxydecanoate sodium
71186-53-350mg960元

常见问题列表

生物活性
5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂 (IC50 约为 30 μM)。5-Hydroxydecanoate sodium 是线粒体外膜酰基辅酶 A 合成酶的底物,并具有抗氧化活性。
靶点

IC50: ~30 μM (K ATP )

体外研究

5-Hydroxydecanoate (5-HD) treatment abolishs the beneficial effects of penehyclidine hydrochloride (PHC) preconditioning in anoxia/reoxygenation (A/R)‐induced injury in H9c2 cells. 5-Hydroxydecanoate blocks the inhibitory effect of PHC on Ca 2+ overload and ROS production. 5-Hydroxydecanoate promotes the release of Cyt-C from mitochondria into cytoplasm. 5-Hydroxydecanoate attenuats the anti-apoptotic effect of PHC. PHC treatment shows remarkably decreases levels of Bax and cleaved caspase-3, and increases levels of Bcl-2. 5-Hydroxydecanoate pretreatment reverses the effects of PHC on their expression levels. 5-Hydroxydecanoate blocks the effects of PHC on K ATP channels.

体内研究

5-Hydroxydecanoate (100 μM) treatment abolishes the effects of ischemic preconditioning (IPC) on the contractile recovery and does not affect its effect on the contracture, lactate production, glycogenolysis and viable tissue in rats.

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