88349-90-0
中文名称
2-[(5-氯-8-喹啉基)氧基]乙酸乙酯
英文名称
ST072042
CAS
88349-90-0
分子式
C13H12ClNO3
分子量
265.69
MOL 文件
88349-90-0.mol
更新日期
2024/04/14 10:33:08
88349-90-0 结构式
基本信息
中文别名
2-[(5-氯-8-喹啉基)氧基]乙酸乙酯 英文别名
A2793ST072042
ethyl 2-(5-chloroquinolin-8-yl)oxyacetate
ethyl [(5-chloroquinolin-8-yl)oxy]acetate
ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate
ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate
2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester
Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester
物理化学性质
沸点393.4±27.0 °C(Predicted)
密度1.291±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 100 mg/mL (376.38 mM)
酸度系数(pKa)1.97±0.29(Predicted)
常见问题列表
生物活性
A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) 是 TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) 和 TASK-1 (KCNK3)，对于小鼠TRESK的IC50值为6.8 μM。靶点
| Target | Value |
|
mTRESK
(Cell-free assay) | 6.8 μM |
体外研究
A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
A2793 inhibits TASK-1 (100 µM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences
TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.