88377-68-8
中文名称
TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2
英文名称
ADRENORPHIN
CAS
88377-68-8
分子式
C44H69N15O9S
分子量
984.18
MOL 文件
88377-68-8.mol
更新日期
2024/06/02 19:54:11
88377-68-8 结构式
基本信息
中文别名
YV-8-NH2受体激动剂多肽METORPHAMIDE
化合物ADRENORPHIN(3TFA)
英文别名
METORPHINADRENORPHIN
METORPHAMIDE
METORPHINAMIDE
Adrenorphin(3TFA)
adrenorphin amide
ADRENORPHIN (BOVINE)
Adrenorphin (metorphamide)
Tyr-Gly-Gly-Phe-Arg-Arg-Val-NH2
PROENKEPHALIN (206-213) (BOVINE)
物理化学性质
密度1.42±0.1 g/cm3(Predicted)
储存条件−20°C
溶解度insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO
酸度系数(pKa)9.97±0.15(Predicted)
形态固体
序列H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2
常见问题列表
生物活性
Adrenorphin 是一种阿片八肽,为 μ-opioid 受体激动剂,Ki 值为 12 nM。靶点
Ki: 12 nM (μ-opioid receptor)
体外研究
Adrenorphin (Metorphamide) is a opioid octapeptide from bovine brain, acts as a potent agonist of μ-opioid receptor, with K i of 12 nM. The binding ratios of K i for μ-opioid receptor/K i for δ-opioid receptor of 0.04 and of K i for μ-opioid receptor/K i for κ-opioid receptor of 0.46. Adrenorphin potently inhibits catecholamine secretion evoked by 10 μM nicotine in cultured human pheochromocytoma 6 cells, with an IC 50 of 1.1 μM.