88678-67-5
88678-67-5 结构式
基本信息
椑草畏
稗草畏
稗草畏标准物质
稗草丹 标准品
稗草丹(稗草畏)
甲苯中稗草丹标准品
甲醇中稗草丹溶液,100ΜG/ML
O-3-特丁基苯基-6-甲氧基-2-吡啶(甲基)硫代氨基甲酸酯
O-3-特丁基苯基-6-甲氧基-2-(吡啶(甲基)硫代氨基甲酸酯
Seexet
tsh-888
Oryzaguard
henyl)ester
PYRIBUTYCARB
PYRIBUTICARB
Pyributicarb [iso]
Pyributicarb Reference Material
Pyributicarb@100 μg/mL in Methanol
物理化学性质
常见问题列表
CYP3A4, hPXR
Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF).
Pyributicarb causes enhancement of CYP3A4 -derived reporter activity in mouse livers introduced with hPXR by adenovirus.